Azithromycin Treatment Failure inMycoplasma genitalium–Positive Patients with Nongonococcal Urethritis Is Associated with Induced Macrolide Resistance

Azithromycin treatment failure in Mycoplasma genitalium-positive patients with nongonococcal urethritis is associated with induced macrolide resistance.

BACKGROUND Mycoplasma genitalium is a common cause of nongonococcal urethritis. Treatment trials have shown that doxycycline is inefficient, whereas a 5-day course of azithromycin eradicates the bacterium from 95% of infected men. The aim of the study was to establish the reason for the occasional treatment failures. METHODS Seven M. genitalium strains isolated from men who experienced azithr...

Induced macrolide resistance in Mycoplasma genitalium isolates from patients with recurrent nongonococcal urethritis.

Mycoplasma genitalium accounts for as much as 15 to 20% of cases of male nongonococcal urethritis (NGU) (7). It is also implicated in female cervicitis and increasingly so in pelvic inflammatory disease (3). Since it is a fastidious microorganism that is very difficult to culture, nucleic acid amplification tests (NAAT) have become invaluable in its detection and microbiological evaluation. Cur...

Psychological pattern of patients with nongonococcal urethritis.

Nongonococcal urethritis associated with T strains of mycoplasma. MF12.524.009-80003.12.

The biological properties of T strains of mycoplasma, the development of methods for their isolation and cultivation, their detection in clinical exudates by means of the urease reaction, and their identification by laboratory methods are reviewed. The current status of T-strain mycoplasma-associated nongonococcal urethritis in the male is reviewed and discussed. Evidence in support of the infe...

Possible Transmission of mcr-1–Harboring Escherichia coli between Companion Animals and Human

described in France in 2012 (14%). We found 35 A→G substitutions at position 2058 or 2059, two A2062T mutations and one A2059C mutation (Table) (1,9). Notably, in patients 15 and 33, who were infected with strains with macrolide resistance–associated mutations, M. genitalium infection was unsuccessfully treated with azithromycin, with treatment failures after azithromycin (1 g) and extended azi...